Gene environment interaction studies in depression and suicidal behavior: An update
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- 作者：Laura M ; elli ; Aless ; ro Serretti
- 关键词：ABCG1 ; ATP-binding cassette subfamily G member 1 ; ACE ; angiotensin-converting enzyme ; APOE ; apoliprotein E ; AVPR1B ; argivanine vasopressin receptor 1B ; BDNF ; brain-derived neurotrophic factor ; CNR1 ; cannabinoid receptor 1 ; COMT ; catechol-O-methyltransferase A ; CRH ; corticotrophin-releasing hormone ; CRHBP ; corticotrophin-releasing hormone binding protein ; CRHR1 ; corticotrophin-releasing hormone receptor 1 ; CRHR2 ; corticotrophin-releasing hormone receptor 2 ; DBH ; dopamine beta-hydroxylase ; DRD1 ; d
- 刊名：Neuroscience and Biobehavioral Reviews
- 出版年：December, 2013
- 年：2013
- 卷：37
- 期：10_part_P1
- 页码：2375-2397
- 全文大小：1677 K
文摘
Increasing evidence supports the involvement of both heritable and environmental risk factors in major depression (MD) and suicidal behavior (SB). Studies investigating gene-environment interaction (G 脳 E) may be useful for elucidating the role of biological mechanisms in the risk for mental disorders. In the present paper, we review the literature regarding the interaction between genes modulating brain functions and stressful life events in the etiology of MD and SB and discuss their potential added benefit compared to genetic studies only. Within the context of G 脳 E investigation, thus far, only a few reliable results have been obtained, although some genes have consistently shown interactive effects with environmental risk in MD and, to a lesser extent, in SB. Further investigation is required to disentangle the direct and mediated effects that are common or specific to MD and SB. Since traditional G 脳 E studies overall suffer from important methodological limitations, further effort is required to develop novel methodological strategies with an interdisciplinary approach.