Topological Regulation of Synaptic AMPA Receptor Expression by the RNA-Binding Protein CPEB3
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- 作者：Iaroslav Savtchouk1 ; 2 ; 5 ; Lu Sun1 ; 2 ; 5 ; Crhistian L. Bender1 ; 5 ; Qian Yang1 ; 5 ; Gá ; bor Szabó ; 4 ; Sonia Gasparini1 ; 3 ; Siqiong June Liu1 ; 2 ; 6 ; sliu@lsuhsc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMPA receptor ; subunit composition ; CPEB3 ; dendritic gradient ; topostatic plasticity ; GluA2 ; cerebellar stellate cell ; PKC ; calcium imaging ; action potentials
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：27 September 2016
- 年：2016
- 卷：17
- 期：1
- 页码：86-103
- 全文大小：3481 K
文摘
Synaptic GluA2-containing AMPA receptors increase along dendrites of stellate cells
Postsynaptic action potentials and graded Ca2+ entry drive the GluA2 gradient
Action potential firing activates PKC and elevates CPEB3 expression
Elevated CPEB3 levels at proximal dendrites suppress GluA2 protein synthesis