Serotonergic systems in the balance: CRHR1 and CRHR2 differentially control stress-induced serotonin synthesis
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- 作者：Nina C. Donnera ; b ; nina_donner@psych.mpg.de" class="auth_mail" title="E-mail the corresponding author ; Philip H. Sieblera ; Danté ; T. Johnsona ; Marcos D. Villarreala ; Sofia Mania ; Allison J. Mattia ; Christopher A. Lowrya
- 关键词：Serotonin ; Tryptophan hydroxylase ; Corticotropin receptor ; Stress ; Glucocorticoids ; Dorsal raphe nucleus
- 刊名：Psychoneuroendocrinology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：63
- 期：Complete
- 页码：178-190
- 全文大小：3582 K
文摘
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Chronic corticosterone abolished the diurnal variance of TPH2 protein expression.
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Chronic corticosterone sensitized in vivo TPH2 activity towards acoustic startle.
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Local CRHR1 blockade potentiated stress-induced TPH2 activity increases in the DR.
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Local CRHR2 blockade prevented stress-induced TPH2 activity increases in the DR.
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TPH2 activity in the caudal pontine reticular nucleus predicted startle response.