Expression of mRNA in the frontal cortex and hypothalamus in a rat model of acute carbon dioxide poisoning
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- 作者：Kazuo Satoa ; b ; Akiko Tsujia ; Yosuke Usumotoa ; Keiko Kudoa ; Takeshi Yokoyamab ; Noriaki Ikedaa ; n-ikeda@forensic.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Agps ; alkylglycerone phosphate synthase ; Car1 ; carbonic anhydrase 1 ; CRH ; corticotropin releasing hormone ; Crhr2 ; corticotropin releasing hormone receptor 2 ; FDR ; False Discovery Rate ; GO ; Gene Ontology ; Hspb2 ; heat shock protein beta 2 ; Hcrt ; hypocretin ; Hcrtr1 ; hypocretin receptor 1 ; NPY ; neuropeptide Y ; Oprd1 ; opioid receptor delta 1 ; Ppy ; pancreatic polypeptide ; Ren ; renin ; SAM ; significant analysis of microarrays ; Th ; tyrosine hydroxylase
- 刊名：Legal Medicine
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：19
- 期：Complete
- 页码：101-106
- 全文大小：920 K
文摘
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We made a rat model of acute CO2 poisoning and analyzed mRNAs expressed in the brain.
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We selected five candidate genes in the frontal cortex and hypothalamus respectively.
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AGPS, HSPB2 may be involved in the dysfunctional cognition by acute CO2 poisoning.
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PPY, CRHR2 may be involved in the regulation of respiration by acute CO2 poisoning.
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Assays for these mRNAs may help identify acute CO2 poisoning as a cause of death.