Corticotropin-releasing hormone (CRH) stimulates cocaine- and amphetamine-regulated transcript gene (CART1) expression through CRH type 1 receptor (CRHR1) in chicken anterior pituitary
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- 作者：Chunheng Mo1 ; Guoqing Cai1 ; Long Huang ; Qiuyang Deng ; Dongliang Lin ; Lin Cui ; Yajun Wang ; Juan Li ; lijuanscuhk@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chicken ; Pituitary ; Corticotropin-releasing hormone (CRH) ; CART ; CRHR1 ; CRHR2
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2015
- 出版时间：5 December 2015
- 年：2015
- 卷：417
- 期：Complete
- 页码：166-177
- 全文大小：2119 K
文摘
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CART1 peptide is expressed in the caudal and cephalic lobes of chicken anterior pituitary.
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CRH potently stimulates pituitary CART1 expression in chickens.
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Both cCRHR1 and cCRHR2 are functional and co-expressed in chicken pituitary.
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cCRH action on cCART1 expression is mediated by cCRHR1 expressed on corticotrophs.
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Multiple signaling pathways coupled to CRHR1 mediate CRH-induced CART1 expression.