Trismus following radiotherapy to the head and neck is likely to have distinct genotype dependent cause

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• 作者：Andrew J. Lyons ; Siobhan Crichton ; Thomas Pezier
• 关键词：Chemotherapy ; Genotype ; Head and neck ; Radiotherapy ; Trismus
• 刊名：Oral Oncology
• 出版年：2013
• 出版时间：September, 2013
• 年：2013
• 卷：49
• 期：9
• 页码：932-936
• 全文大小：272 K

文摘

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Summary

Objectives

Trismus frequently occurs as a consequence of radiotherapy or chemo-radiotherapy to the head and neck, with a loss of function that can reduce the overall quality of life. Radiation can trigger an intense fibrosis within the masticatory muscles and transforming growth factor beta 1 (TGF ¦Â1) is involved in this process. As in other tissues the degree of fibrosis may be related to a single nucleotide polymorphism; C-T at position ?509 in the TGF ¦Â1 gene.

Materials and methods

Trismus was measured in 62 patients before and after radiotherapy or chemoradiotherapy, blood was taken for DNA extraction, and genotype analysis of the TGF ¦Â1 gene. Trismus was analysed against, patient age, sex, tumour site and stage, radiotherapy, and chemotherapy.

Results and conclusions

After radiotherapy or chemo-radiotherapy the reduction in mouth opening was shown to be significantly related to the presence of the T allele (p < 0.001), with patients homozygous the most likely to be severely affected. No other patient, tumour or treatment factors were significant. Hence the TGF ¦Â1 genotype is likely to be an important predictor of the degree of post radiotherapy or chemo-radiotherapy trismus.