Addition of Metalated Pyrones to β-Alkoxy Aldehydes: Synthesis of Hydroxylated Spiroketals
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文摘
Addition of lithiated γ-pyrones to β-alkoxy aldehydes followed by acid catalyzed spiroketalization provides a rapid efficient entry to functionalized hydroxylated spiroketals. The efficiency of the spiroketalization step is dependent on the substituents, particularly unprotected hydroxyls, on the chain which becomes the second ring of the spiroketal.