Ring closing metathesis for the formation of medium ring ethers: the total synthesis of (−)-isolaurallene

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• 作者：Crimmins ; Michael T. ; Emmitte ; Kyle A. ; Choy ; Allison L.
• 关键词：marine natural products ; isolaurallene ; metathesis ; asymmetric aldol ; asymmetric alkylation ; oxonene
• 刊名：Tetrahedron
• 出版年：2002
• 出版时间：March 4, 2002
• 年：2002
• 卷：58
• 期：10
• 页码：1817-1834
• 全文大小：360 K

文摘

The total synthesis of the marine metabolite (−)-isolaurallene is described. Two approaches to the core nine-membered ether are presented both of which are based on a ring closing metathesis to close the cyclic ether.