Hyaluronic acid alkyl derivative: A novel inhibitor of metalloproteases and hyaluronidases
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- 作者：Mauro Pavan ; Devis Galesso ; Cynthia Secchieri ; Cristian Guarise ; cguarise@fidiapharma.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Matrix metalloproteinase (MMP) ; Hyaluronan ; Osteoarthritis
- 刊名：International Journal of Biological Macromolecules
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：84
- 期：Complete
- 页码：221-226
- 全文大小：876 K
文摘
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A bioactive alkyl derivative of HA was selected among other GAG derivative.
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HA hexadecyl derivative showed higher inhibition potency against MMP13 and MMP8.
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Human MMP13 and Hyal-2 inhibition were demonstrated in synovial fluid.
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HA derivatization gave biological activity in addition to mechanical properties.