Emotional stress and sympathetic activity: Contribution of dorsomedial hypothalamus to cardiac arrhythmias

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• 作者：Marco Antô ; nio Peliky Fontes^a ; ^{peliky@icb.ufmg.br" class="auth_mail} ; Carlos Henrique Xavier^c ; Fernanda Ribeiro Marins^a ; Marcelo Limborç ; o-Filho^a ; Gisele Cristiane Vaz^a ; Flá ; via Camargos Mü ; ller-Ribeiro^a ; Eugene Nalivaiko^b
• 关键词：Sympathetic activity ; Emotional stress ; Dorsomedial hypothalamus ; Cardiac arrythmias
• 刊名：Brain Research
• 出版年：20 March, 2014
• 年：2014
• 卷：1554
• 期：Complete
• 页码：49-58
• 全文大小：615 K

文摘

Maintenance of homeostasis in normal or stressful situations depends upon mechanisms controlling autonomic activity. Central requirement for changes in sympathetic output resulting from emotional stress must be adjusted to the input signals from visceral sensory afferent (feedback response) for an optimum cardiovascular performance. There is a large body of evidence indicating that emotional stress can lead to cardiovascular disease. Reviewing the descending pathways from dorsomedial hypothalamus, a key region involved in the cardiovascular response to emotional stress, we discuss the interactions between mechanisms controlling the sympathetic output to the cardiovascular system and the possible implications in cardiovascular disease.