Lamin A is involved in the development of vascular calcification induced by chronic kidney failure and phosphorus load
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- 作者：Isabel Quiró ; s-Gonzá ; leza ; 1 ; 2 ; Pablo Romá ; n-Garcí ; aa ; 1 ; Cristina Alonso-Montesa ; 1 ; Sara Barrio-Vá ; zqueza ; Natalia Carrillo-Ló ; peza ; Manuel Naves-Dí ; aza ; Marí ; a Isabel Morab ; Fernando José ; Corralesb ; Francisco J. Ló ; pez-Herná ; ndezc ; Marí ; a Piedad Ruiz-Torresd ; Jorge Benito Cannata-Andí ; aa ; cannata@hca.es" class="auth_mail" title="E-mail the corresponding author ; José ; Luis Ferná ; ndez-Martí ; na
- 关键词：Vascular calcification ; Phosphorus load ; Chronic kidney disease ; Ageing ; Runx2 ; Animal models ; Proteomics ; Lamin a
- 刊名：Bone
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：84
- 期：Complete
- 页码：160-168
- 全文大小：990 K
文摘
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A high-phosphorus diet induced severe vascular calcification, decrease of renal function and higher mortality in uremic rats.
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Proteomics showed a distinct protein expression between non-calcified and calcified aortas, with lamin increase in the latter.
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VSMCs in calcifying media showed an increased binding of lamin with RUNX2, a major pro-osteoblastic transcription factor.
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Successful silencing of lamin prevented VSMCs' calcification and impaired the nuclear localization of RUNX2.
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Lamin A could play a key role in vascular calcification partly facilitating the nuclear localization of RUNX2.