Bilirubin and tryptophan adsorption in albumin-containing solutions: I. Equilibrium isotherms on activated carbon

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• 作者：Maria Cristina Annesini ; Chiara Di Carlo ; Vincenzo Piemonte ; Luca Turchetti
• 关键词：Adsorption ; Amino acid ; Artificial liver ; Bilirubin ; Modelling ; Artificial liver
• 刊名：Biochemical Engineering Journal
• 出版年：2008
• 出版时间：1 June 2008
• 年：2008
• 卷：40
• 期：2
• 页码：205-210
• 全文大小：222 K

文摘

Albumin-bound toxins are involved in the aetiology of many liver failure associated pathologies and specific processes aimed to their removal have been developed. In general, adsorption plays an important role in all of these processes. In this paper, two albumin-bound toxins (bilirubin and tryptophan) were considered and their adsorption equilibrium on activated carbon in albumin-containing solutions was investigated. The experimental results clearly show that the higher the albumin concentration in the liquid phase, the lower the toxin adsorbed amount. This effect was quantitatively analysed by means of a mathematical model that accounts for chemical and non-chemical interactions between albumin and toxin adsorption.