- 作者：Patricia da Silva Fucuta Pereira ; patriciafucuta@gmail.com ; Silvia Naomi de Oliveira Uehara ; Renata de Mello Perez ; Ana Cristina Amaral Feldner ; Isaura Cunha de Melo ; Ivonete Sandra de Souza e Silva ; Antonio Eduardo Benedito Silva ; Maria Lucia Gomes Ferraz
- 关键词：Dialysis ; Hepatitis C ; HCV RNA ; Interferon ; Predictive value
- 刊名：International Journal of Infectious Diseases
- 出版年：2013
- 出版时间：January, 2013
- 年：2013
- 卷：17
- 期：1
- 页码：e50-e53
- 全文大小：246 K
Summary
Objective
The aim of the present study was to determine whether hepatitis C virus (HCV) RNA present at week 12 is a good predictor of the response to interferon (IFN) monotherapy in hemodialysis patients with hepatitis C.Methods
Hemodialysis patients with hepatitis C who were treated between 1997 and 2008 with IFN monotherapy for 48 weeks without dose reduction were included. The predictive value of HCV RNA at week 12 for achieving a sustained virological response (SVR) was determined.
Results
Forty patients (mean age 47 ¡À 9 years; 75 % males and 80 % with genotype 1) were included. Septal fibrosis or cirrhosis was observed in 38 % of these patients. Twelve (30 % ) of the 40 patients achieved SVR. HCV RNA was undetectable at week 12 in 68 % . The positive predictive value of HCV RNA at week 12 was 45 % and the negative predictive value was 100 % .
Conclusions
The presence of HCV RNA at week 12 had a high negative predictive value for SVR in hemodialysis patients with chronic hepatitis C treated with IFN for 48 weeks. Therefore, if HCV RNA is detected at week 12, treatment should be discontinued due to the low probability of a sustained response.