Skin aging in patients with acquired immunodeficiency syndrome

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• 作者：Grace Kelly Naves de Aquino Favarato ; Aline Cristina Souza da Silva ; Lí ; via Ferreira Oliveira ; Mara Lú ; cia da Fonseca Ferraz ; Vicente de Paula Antunes Teixeira ; Camila Lourencini Cavellani ; ^{camila@patge.uftm.edu.br" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Skin ; Acquired immunodeficiency syndrome ; Aging ; Epidermis
• 刊名：Annals of Diagnostic Pathology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：24
• 期：Complete
• 页码：35-39
• 全文大小：650 K

文摘

To evaluate the histomorphometric skin changes over aging patients with autopsied acquired immunodeficiency syndrome (AIDS). In 29 skin fragments of autopsied elderly (older than 50 years) and nonelderly patients with AIDS, epidermal thickness, the number of layers, the diameter of cells, the percentage of collagen and elastic fibers in the dermis, and the number and morphology of Langerhans cells were assessed. Statistical analysis was performed by SigmaStat 2.03 program. The thickness of the epidermis (92.55 × 158.94 μm), the number of layers (7 × 9 layers), and the diameter of the cells (13.27 × 17.6 μm) were statistically lower among the elderly. The quantity of collagen fibers (9.68 × 14.11%) and elastic fibers (11.89 × 15.31%) was also significantly lower in the elderly. There was a decrease in total (10.61 × 12.38 cel/mm²) and an increase in immature Langerhans cells (6.31 × 4.98 cel/mm²) in elderly patients with AIDS. The aging of the skin of patients with AIDS is amended in different histomorphometric aspects, the epidermis constituents suffer less pronounced changes in normal aging, and the dermis has more intense changes in elastic fibers and collagen.