Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth
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- 作者：Zhiqiang Lin1 ; zlin@enders.tch.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Haidong Guo1 ; 2 ; Yuan Cao1 ; 3 ; Sylvia Zohrabian1 ; Pingzhu Zhou1 ; Qing Ma1 ; Nathan VanDusen1 ; Yuxuan Guo1 ; Jin Zhang1 ; Sean M. Stevens1 ; Feng Liang4 ; Qimin Quan4 ; Pim R. van Gorp5 ; Amy Li6 ; Cristobal dos Remedios6 ; Aibin He7 ; Vassilios J. Bezzerides1 ; William T. Pu1 ; 8 ; 9 ; wpu@pulab.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：cardiac ; cardiomyocyte ; proliferation ; necrosis ; Hippo-YAP pathway ; TEAD1 ; VGLL4 ; acetylation ; degradation
- 刊名：Developmental Cell
- 出版年：2016
- 出版时间：21 November 2016
- 年：2016
- 卷：39
- 期：4
- 页码：466-479
- 全文大小：3636 K
文摘
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TEAD-YAP stimulates organ growth, but its regulation is incompletely understood
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p300-mediated acetylation of VGLL4 K225 regulates VGLL4 antagonism of TEAD-YAP
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VGLL4-TEAD1 interaction promotes TEAD1 degradation
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VGLL4-K225Ac regulates TEAD1 activity to allow normal heart development