PPARγ agonist pioglitazone improves cerebellar dysfunction at pre-Aβ deposition stage in APPswe/PS1dE9 Alzheimer's disease model mice
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- 作者：Junya Tobaa ; Miyu Nikkunia ; Masato Ishizekib ; Aya Yoshiia ; Naoto Watamuraa ; Takafumi Inoueb ; Toshio Ohshimaa ; ohshima@waseda.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alzheimer's disease ; Protein phosphorylation ; CRMP ; Mouse ; Cerebellum
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：13 May 2016
- 年：2016
- 卷：473
- 期：4
- 页码：1039-1044
- 全文大小：873 K
文摘
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Phosphorylation level of CRMP2 increased in the cerebellum of APP/PS1 mice.
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p35 protein levels increased in the cerebellum of APP/PS1 mice.
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Pioglitazone treatment improved cerebellar dysfunction of APP/PS1 mice.