Cross-talk between α7 nAchR and NMDAR revealed by protein profiling
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- 作者：Hailong Zhanga ; Tao Lia ; b ; Shupeng Lia ; c ; Fang Liua ; c ; f.liu.a@utoronto.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Protein&ndash ; protein interaction ; α7nAchR ; NMDAR ; Label-free quantitative proteomics approach ; Biological pathway ; Neurotransmitters
- 刊名：Journal of Proteomics
- 出版年：2016
- 出版时间：10 January 2016
- 年：2016
- 卷：131
- 期：Complete
- 页码：113-121
- 全文大小：1213 K
文摘
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An extensive molecular profiling to analyze cross-talk of α7nAchR and NMDAR in the rat brain has been carried out
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Rewiring biological network of differently expressed proteins under choline/NMDAR showed 21 kind of biological pathways involved
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Western blot analysis verified proteins expression determined by LC-MS
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Protein expression in vivo in neurons from fetal rats were visualized and quantified by Confocal microscopy
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The neurotransmitters (dopamine, glutamate, GABA and 5-HT) were measured