Skeletal muscle cells express Nox1, Nox2, and Nox4 isoforms and subunits.
Nox2 and Nox4 are critical sources of skeletal muscle ROS in health and disease.
Recent studies suggest unique aspects of Nox2 and Nox4 in skeletal muscle.
Several studies suggest a cross-talk between Nox2 and mitochondrial ROS.