Cross-Neutralizing and Protective Human Antibody Specificities to Poxvirus Infections
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- 作者：Iuliia Gilchuk1 ; Pavlo Gilchuk2 ; 3 ; Gopal Sapparapu1 ; 4 ; Rebecca Lampley1 ; Vidisha Singh1 ; Nurgun Kose1 ; David L. Blum1 ; Laura J. Hughes5 ; Panayampalli S. Satheshkumar5 ; Michael B. Townsend5 ; Ashley V. Kondas5 ; Zachary Reed5 ; 6 ; Zachary Weiner6 ; Victoria A. Olson5 ; Erika Hammarlund7 ; Hans-Peter Raue7 ; Mark K. Slifka7 ; James C. Slaughter8 ; Barney S. Graham9 ; Kathryn M. Edwards4 ; Roselyn J. Eisenberg10 ; Gary H. Cohen11 ; Sebastian Joyce2 ; 3 ; James E. Crowe Jr.1 ; 2 ; 4 ; 12 ; james.crowe@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：smallpox vaccine ; poxvirus infections ; human monoclonal antibodies ; antigen specificity ; cross-neutralization ; protective immunity
- 刊名：Cell
- 出版年：2016
- 出版时间：20 October 2016
- 年：2016
- 卷：167
- 期：3
- 页码：684-694.e9
- 全文大小：2149 K
文摘
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Orthopoxviruses elicit a complex B cell immune response reactive to diverse antigens
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A large fraction of orthopoxvirus neutralizing mAbs possess cross-neutralizing activity
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Six principal mAb specificities participate in cross-neutralization and protection
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Most efficient protection is achieved by mixture of diverse mAbs specificities