Identification of emergent bla_CMY-2-carrying Proteus mirabilis lineages by whole-genome sequencing

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• 作者：M. Mac Aog&aacute ; inp>1p>p> ; p>p>m.macaogain@tcd.ie" class="auth_mail" title="E-mail the corresponding authorp> ; T.R. Rogersp>1p>p> ; p>p>2p> ; B. Crowleyp>1p>p> ; p>p>2p>
• 关键词：blaCMY-2 ; genomics ; ICE ; PGI-1 ; Proteus mirabilis
• 刊名：New Microbes and New Infections
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：9
• 期：Complete
• 页码：58-62
• 全文大小：576 K

文摘

Whole-genome sequencing of 24 Proteus mirabilis isolates revealed the clonal expansion of two cefoxitin-resistant strains among patients with community-onset infection. These strains harboured bla_CMY-2 within a chromosomally located integrative and conjugative element and exhibited multidrug resistance phenotypes. A predominant strain, identified in 18 patients, also harboured the PGI-1 genomic island and associated resistance genes, accounting for its broader antibiotic resistance profile. The identification of these novel multidrug-resistant strains among community-onset infections suggests that they are endemic to this region and represent emergent P. mirabilis lineages of clinical significance.