Gestational maternal C-­reactive protein and risk of bipolar disorder among young individuals in a Nationwide Birth Cohort

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• 作者：Roshan Chudal^a ; ¹ ; ^{roschu@utu.fi} ; Andre Sourander^a ; ¹ ; Heljä ; -Marja Surcel^b ; Dan Sucksdorff^a ; Susanna Hinkka-Yli-Salomä ; ki^a ; Alan S. Brown^c ; ^d
• 关键词：CRP ; Bipolar disorder ; Prenatal inflammation ; Nationwide cohort ; Epidemiology
• 刊名：Journal of Affective Disorders
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：208
• 期：Complete
• 页码：41-46
• 全文大小：294 K
• 卷排序：208

文摘

Inflammation in pregnancy is associated with increased risk of psychiatric disorders. CRP is marker of inflammation from both infectious and noninfectious exposures. Elevated maternal CRP is associated with an increased risk of schizophrenia and ASD. No significant associations were seen with elevated maternal CRP and offspring BPD. Maternal inflammation may be a factor that differentiates schizophrenia from BPD.