CSF-1 receptor signalling is governed by pre-requisite EHD1 mediated receptor display on the macrophage cell surface
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- 作者：Luke R. Cyphera ; Timothy Alan Bieleckia ; Lu Huangd ; Wei Anb ; Fany Isekab ; Eric Tomc ; Matthew D. Storcka ; Adam D. Hopped ; Vimla Banda ; b ; Hamid Banda ; b ; hband@unmc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CSF1R ; colony stimulating factor 1 receptor ; CSF1 ; colony stimulating factor-1 ; BMDM ; bone marrow derived macrophage ; EHD1 ; Eps-15 homology domain-containing protein 1 ; EHD1-KO ; EHD1-knockout (4-hydroxytamoxifen induced deletion) ; RTK ; receptor tyrosine kinase ; TAM ; 4-hydroxytamoxifen ; FACS ; fluorescence activated cell sorting ; c.p.m. ; counts per minute ; GM130 ; golgi matrix protein (130 ; kD) ; LAMP1 ; lysosomal associated membrane protein 1 ; PFA ; paraformaldehyde ; BSA ; bovine serum albumin
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：28
- 期：9
- 页码：1325-1335
- 全文大小：1466 K
文摘
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CSF-1R transport and display at the cell surface have not been studied in depth.
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A novel function for EHD1 in anterograde trafficking of CSF-1R was discovered.
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EHD1 was found to be essential for CSF-1R presentation on the macrophage cell surface.
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Targeting of CSF-1R presentation to the cell surface may improve diseases in which CSF-1R signalling is aberrant.