Default mode network connectivity is linked to cognitive functioning and CSF Aβ1-42 levels in Alzheimer’s disease
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- 作者：Ozlem Celebia ; Andac Uzdoganb ; Kader Karli Oguzc ; Arzu Ceylan Hasd ; Anil Dolgune ; Gul Yalcin Cakmaklia ; Filiz Akbiyikb ; Bulent Elibolf ; Esen Sakaf ; esensaka@hacettepe.edu.tr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alzheimer&rsquo ; s disease ; Biomarker ; Cognition ; Resting functional magnetic resonance imaging ; Posterior cingulate cortex ; Retrosplenial cortex
- 刊名：Archives of Gerontology and Geriatrics
- 出版年：2016
- 出版时间：January-February 2016
- 年：2016
- 卷：62
- 期：Complete
- 页码：125-132
- 全文大小：1328 K
文摘
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Default mode network (DNM) functional connectivity in rest-fMRI is altered in AD.
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Cognitive functions are closely linked to DMN functional connectivity changes.
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CSF Aβ1–42 level is related to connectivity changes in specific DMN nodes in AD.