We developed mice deficient in Chst14, pivotal enzyme by generation of dermatan sulfate.
We performed spinal cord injury in Chst14-deficient mice (Chst14−/−).
We observed reduced locomotor recovery after spinal cord injury in Chst14−/− versus Chst14+/+ mice.
Chst14 ablation slightly reduced axonal regeneration, and had no effect on glial scar formation.