Formulation optimization and characterization of transdermal film of simvastatin by response surface methodology
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- 作者：Rabinarayan Parhia ; bhu_rabi@rediffmail.com" class="auth_mail" title="E-mail the corresponding author ; Padilam Sureshb
- 关键词：Simvastatin ; Transdermal film ; Hypolipidemic activity ; Box&ndash ; Behnken design
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：58
- 期：Complete
- 页码：331-341
- 全文大小：1823 K
文摘
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PVA/EG based matrix films of SS were designed and optimized using RSM.
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DBT and SS concentrations had highest impact on tensile strength and flux, respectively.
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Predicted composition of SSTF was 2% of SS, 2:1 ratio of PVA:EG and 40% of DBT.
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Optimized SSTF exhibited tensile strength of 11.871 MPS and flux of 43.569 渭g/cm2/h.
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Optimized SSTF exhibited significant lowering of TC, TG, and VLDL level in blood.