Stability and biocompatibility of photothermal gold nanorods after lyophilization and sterilization
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- 作者：Leyre Gomez ; Virginia Cebrian ; Francisco Martin-Saavedra ; Manuel Arruebo ; Nuria Vilaboa ; Jesus Santamaria
- 关键词：A. nanostructures ; A. metals ; D. optical properties ; B. chemical synthesis
- 刊名：Materials Research Bulletin
- 出版年：2013
- 出版时间：October, 2013
- 年：2013
- 卷：48
- 期：10
- 页码：4051-4057
- 全文大小：1254 K
文摘
Suspensions in phosphate buffered saline (PBS) of gold nanorods stabilized with cetyltrimethyl ammonium chloride (CTABr), polystyrenesulfonate (PSS) and methyl-polyethyleneglycol-thiol (m-PEG-SH) have been prepared and the evolution of their colloidal stability and plasmonic response over time has been evaluated. Their performance after lyophilization, alcoholic sterilization and resuspension has also been characterized. Sub-cytotoxic doses on HeLa cells were calculated for the three surface functionalizations used. Their heating efficiency at different exposure times was also evaluated after being irradiated with near infrared light. The best results were obtained for m-PEG-SH stabilized rods, which were not only stable, sterilizable and lyophilizable, but also biocompatible at all doses tested, showing potential as a stable, re-suspendible and biocompatible hyperthermic agent.