Autoantibody Production in Cancer—The Humoral Immune Response toward Autologous Antigens in Cancer Patients

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• 作者：P. Zaenker^a ; ^{p.zaenker@ecu.edu.au" class="auth_mail" title="E-mail the corresponding author} ; E.S. Gray^a ; M.R. Ziman^a ; ^b
• 关键词：dsDNA ; double-stranded DNA ; MIF ; macrophage migration inhibitory factor ; Ang-2 ; angiopoietin 2 ; CENPF ; centromere protein F ; Her2/neu ; human epidermal growth factor receptor 2 ; MUC1 ; mucin 1 ; IMP2 ; insulin-like growth factor mRNA-binding family member 2 ; AORF ; alternative open reading frame ; CTAG1B/NY-ESO-1 ; cancer testis antigen 1B ; OGFr ; opioid growth factor receptor ; PSA ; prostate-specific antigen ; TNF ; tumor necrosis factor ; MAGEA3 ; melanoma antigen A3 ; PASD1 ; cancer antigen containing the P
• 刊名：Autoimmunity Reviews
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：15
• 期：5
• 页码：477-483
• 全文大小：685 K

文摘

A link between autoimmune responses and cancer via autoantibodies was first described in the 1950s. Since, autoantibodies have been studied for their potential use as cancer biomarkers, however the exact causes of their production remain to be elucidated. This review summarizes current theories of the causes of autoantibody production in cancer, namely: 1) defects in tolerance and inflammation, 2) changes in protein expression levels, 3) altered protein structure, and 4) cellular death mechanisms. We also highlight the need for further research into this field to improve our understanding of autoantibodies as biomarkers for cancer development and progression.