Modeling techniques and fluorescence imaging investigation of the interactions of an anthraquinone derivative with HSA and ctDNA
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- 作者：Zheng Fua ; b ; Yanrui Cuia ; Fengling Cuia ; fenglingcui@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Guisheng Zhanga
- 关键词：Anthraquinone ; HSA ; ctDNA ; Fluorescence spectroscopy ; Molecular modeling ; Bioimaging
- 刊名：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：153
- 期：Complete
- 页码：572-579
- 全文大小：1200 K
文摘
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A new anthraquinone derivative (AORha) was synthesized.
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The mechanisms between AORha and HSA, ctDNA were studied simultaneously.
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HepG2 cells were used for cell viability assay and cell imaging experiment.
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The binding constant, binding site and distance of hydrogen bond were also obtained.