A specific CpG oligodeoxynucleotide induces protective antiviral responses against grass carp reovirus in grass carp Ctenopharyngodon idella
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- 作者：Hang Sua ; b ; Gailing Yuana ; b ; Jianguo Sua ; b ; sujianguo@mail.hzau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Grass carp (Ctenopharyngodon idella) ; Grass carp reovirus ; CpG oligodeoxynucleotides ; Toll-like signaling pathway ; RIG-I-like signaling pathway ; Interferon
- 刊名：Developmental & Comparative Immunology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：60
- 期：Complete
- 页码：218-227
- 全文大小：3878 K
文摘
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Found a CpG ODN, 1670A, containing the optimal sequence with strong immune stimulatory and antiviral activity in grass carp.
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CpG ODN induced immune response by TLR9 signaling pathway largely.
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TLR21 did not play a role in the immune response to CpG ODN.
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RLRs participated in the immune response caused by the efficient CpG ODN.
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IFNγ2 played an important role in response to the efficient CpG ODN.