Immune signature of urothelial cancer associated with grade, recurrence, and invasion
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- 作者：Usha Agrawal ; M.D.a ; b ; 1 ; Nitu Kumari ; M.Sc.a ; c ; 1 ; Ashwani K. Mishra ; Ph.D.d ; Pawan Vasudeva ; M.Ch.e ; Anup Kumar ; M.Ch.e ; Nayan K. Mohanty ; M.S. ; M.Ch.f ; Sunita Saxena ; M.D.a ; sunita_saxena@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; uburra@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Urothelial cancer ; Cytokines ; NFκB ; CTLA4
- 刊名：Urologic Oncology: Seminars and Original Investigations
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：34
- 期：9
- 页码：418.e17-418.e26
- 全文大小：1411 K
文摘
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Paired tumor and normal tissue of urinary bladder were evaluated for gene expression.
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NFκB and cytokine pathways genes were evaluated by pathway-focused array.
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Dysregulated hub genes selected by Network analysis were validated.
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Up-regulated IL10 and CTLA4 were associated with poor recurrence-free survival.
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High urinary CTLA4 was associated with poor recurrence-free survival.