Cationic P(CL)2-PEG copolymers were successfully synthesized by click reaction. Cationic ligand had an effect on Tg and Tm of copolymers higher than P(CL) length. P(CL) length and cationic ligand content affected particle size and morphology. pH and NaCl greatly affected stability of high cationic and long chain particles. Properties of particles changed after entrapment of negatively charged drug.