Epidemiological and clinical characteristics of nosocomial candidiasis in university hospitals in Cuiab¨¢ - Mato Grosso, Brazil

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• 作者：Ana Caroline Akeme Yamamoto^a ; Claudete Rodrigues de Paula^c ; Luciana Basili Dias^a ; Tomoko Tadano^b ; É ; velin Rodrigues Martins^a ; Janaí ; na Vasconcelos Ribeiro de Souza Amadio^a ; Rosane Christine Hahn^a ; ^b ; ^{rchahn@terra.com.br}
• 关键词：Nosocomial ; Risk factors ; Candida spp. ; Epidemiology
• 刊名：Revista Iberoamericana de Micolog¨ªa
• 出版年：2012
• 出版时间：July-September, 2012
• 年：2012
• 卷：29
• 期：3
• 页码：164-168
• 全文大小：184 K

文摘

Background

Fungal infections are emerging as an important cause of human disease, especially among hospitalized patients with serious underlying disease and several risk factors.

Aims

To evaluate epidemiological and clinical characteristics of patients with nosocomial candidiasis in university hospitals in Cuiab¨¢ - MT, Brazil.

Methods

A descriptive study of 91 patients admitted to university hospitals in Cuiab¨¢ - MT, with clinical and laboratory diagnosis of nosocomial candidiasis, over a 20-month period.

Results

A rate for nosocomial infections by Candida spp. of 5 per 1000 admissions, proportional mortality of 14.4 % and lethality of 53.8 % were determined. The patient age ranged from 29 days to 82 years-old, among which, 74.7 % were adults and 25.3 % children. The intensive care units contributed with the highest number of cases of infection by Candida spp. (69.2 % ). The most important underlying disease was gastrointestinal tract disease (11 % ). Prematurity and low birth weight were the most important risk factors among newborns. The use of antibiotics, invasive procedures, H₂ blockers, multiple blood transfusions and stay length of ?1 days were the most frequent risk factors among adults. Candida albicans was the most common species in all cases.

Conclusions

In this study, C. albicans was the most frequently detected species in candidiasis and risk factors increased the susceptibility of hospitalized patients to acquiring a nosocomial infection by Candida spp.