Signal pathways involved in the biological effects of sulfur dioxide

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• 作者：Xin-Bao Wang^a ; ^{xinbaowang2008@163.com" class="auth_mail" title="E-mail the corresponding author} ; Jun-Bao Du^b ; Hong Cui^a ; ^{cuihongl00@sina.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Sulfur dioxide ; Gasotransmitter ; Signal pathway ; Biology
• 刊名：European Journal of Pharmacology
• 出版年：2015
• 出版时间：5 October 2015
• 年：2015
• 卷：764
• 期：Complete
• 页码：94-99
• 全文大小：422 K

文摘

Gasotransmitters, such as nitric oxide, carbon monoxide and hydrogen sulfide, play important roles in life and have attracted great interest in scientists. In recent years, sulfur dioxide (SO₂) has also been found to play important roles in mammals. The redox pathway is involved in the biological effects of SO₂, such as the protective effect on myocardial ischemia reperfusion, myocardial injury, pulmonary hypertension and atherosclerosis. Ion channels, such as L-type calcium and adenosine triphosphate-sensitive potassium channels, as well as 3′–5′-cyclic guanosine monophosphate and 3′–5′-cyclic adenosine monophosphate pathways are also involved in the vasorelaxant effect of SO₂. The mitogen-activated protein kinase pathway plays roles in vascular remodeling during pulmonary hypertension and vascular smooth muscle cell proliferation. Understanding these signaling mechanisms would help to clarify the pathophysiological effect and therapeutic potential of SO₂.