Sulfur dioxide, a double-faced molecule in mammals

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• 作者：Xin-Bao Wang^a ; Jun-Bao Du^b ; ^{junbaodu1@126.com" class="auth_mail} ; Hong Cui^a ; ^{cuihongl00@sina.com" class="auth_mail}
• 关键词：Sulfur dioxide ; Physiological effects ; Pathophysiological effects ; Biology ; Gasotransmitter
• 刊名：Life Sciences
• 出版年：11 March, 2014
• 年：2014
• 卷：98
• 期：2
• 页码：63-67
• 全文大小：377 K

文摘

Sulfur dioxide (SO₂) is a common air pollutant and is detrimental to many organs. Its toxic effects including oxidative damage, deoxyribonucleic acid (DNA) damage and inflammation have been extensively studied. However, recent studies showed that SO₂ can be generated endogenously in mammals. In contrast to the toxic effects of SO₂, protective effects have also been found in mammals. Endogenous SO₂ has antioxidant, anti-inflammatory, anti-hypertension, and anti-atherogenic effects and regulates vascular tone and cardiac function in mammals. SO₂ may have a dual role in regulating physiological and pathophysiological effects in mammals. The biological effects of SO₂ in mammals are reviewed in this study.