Glucose-regulated protein 78 may play a crucial role in promoting the pulmonary microvascular remodeling in a rat model of hepatopulmonary syndrome
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- 作者：Huiying Zhanga ; zhanghy2001@163.com" class="auth_mail ; Minli Lvb ; Zhongfu Zhaoc ; Jiantao Jiaa ; Lili Zhanga ; Peng Xiaod ; Limin Wange ; Chen Lif ; Jingquan Jia ; Xiaoxia Tiana ; Xujiong Lif ; Yimin Fane ; Lina Laig ; Yan Liuf ; Baohong Lia ; Cuiying Zhange ; Mingshe Liuc ; Jianhong Guoh ; Dewu Hanh ; Cheng Jii
- 关键词：GRP78 ; glucose-regulated protein 78 ; HPS ; hepatopulmonary syndrome ; ALT ; alanine transferase ; VEGF ; vascular endothelial growth factor ; FVIII-RAg ; factor VIII-related antigen ; NF-魏B ; nuclear factor-魏B ; ER ; endoplasmic reticulum ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase ; HRP ; horseradish peroxidase
- 刊名：Gene
- 出版年：15 July 2014
- 年：2014
- 卷：545
- 期：1
- 页码：156-162
- 全文大小：1310 K
文摘
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The levels of endotoxin and ALT were gradually increased as HPS progressed.
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The levels of GRP78, FVIII-RAg and VEGF were significantly elevated in HPS rats.
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Pro-apoptotic proteins of CHOP/GADD153 and caspase-12 were dramatically decreased.
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Anti-apoptotic proteins of Bcl-2 and NF-魏B were significantly elevated.
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GRP78 may promote the pulmonary microvascular remodeling in HPS pathogenesis.