The levels of endotoxin and ALT were gradually increased as HPS progressed.
The levels of GRP78, FVIII-RAg and VEGF were significantly elevated in HPS rats.
Pro-apoptotic proteins of CHOP/GADD153 and caspase-12 were dramatically decreased.
Anti-apoptotic proteins of Bcl-2 and NF-魏B were significantly elevated.
GRP78 may promote the pulmonary microvascular remodeling in HPS pathogenesis.