Antiproliferative activity of amino substituted benzo[b]thieno[2,3-b]pyrido[1,2-a]benzimidazoles explored by 2D and 3D cell culture system

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• 作者：Nata&scaron ; a Perin^a ; Kristina Bobanović^b ; Ivo Zlatar^c ; Dubravko Jelić^c ; Vanja Kelava^d ; Sanja Ko&scaron ; trun^d ; Vesna Gabelica Marković^d ; Karmen Braj&scaron ; a^c ; ^{karmen.brajsa@glpg.com} ; Marijana Hranjec^a ; ^{mhranjec@fkit.hr}
• 关键词：Antiproliferative activity ; benzo[b]thieno[2 ; 3-b]pyrido[1 ; 2-a]benzimidazoles ; 2D and 3D in vitro cytotoxicity assay ; Lipophilicity ; Physico-chemical properties
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：125
• 期：Complete
• 页码：722-735
• 全文大小：1646 K
• 卷排序：125

文摘

Amino substituted pentacyclic benzimidazole derivatives with antiproliferative activity. Antiproliferative evaluation by 2D and 3D assays on the human breast cancer cells. 3D assay showed some selective activity on MDA-MB-231 cell line. Physico-chemical properties investigated by multivariate statistical methods.