Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration

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• 作者：Karine Palin ; Colm Cunningham ; Penny Forse ; V. Hugh Perry ; Nick Platt
• 关键词：Axon ; Neurodegeneration ; Microglia ; Lipopolysaccharide
• 刊名：Neurobiology of Disease
• 出版年：2008
• 出版时间：April 2008
• 年：2008
• 卷：30
• 期：1
• 页码：19-29
• 全文大小：2038 K

文摘

Axon loss in the CNS is characteristic of many neurodegenerative diseases but the mechanisms of axon degeneration are poorly understood. In particular, we know little of the inflammatory response triggered by CNS axon degeneration with comparison to that provoked by death of the neuronal cell body. We show that Wallerian degeneration of the mouse optic nerve induces transcription of TGF-β1 and TNF-, but not pro-inflammatory cytokines IL-1β and IL-6 and microglial activation. This atypical inflammatory response resembles macrophages that have phagocytosed apoptotic cells and prion-infected CNS. Significantly, peripheral endotoxin challenge after injury switched this profile by inducing IL-1β, IL-6 transcripts, other inflammation-associated products and reducing neurofilament immunoreactivity. We propose that microglia are activated by Wallerian degeneration and persist in an atypical but “primed” state and can be switched by systemic inflammation to provoke a classical pro-inflammatory profile with potentially deleterious consequences.