Biotransformation of patchoulol by Cunninghamella echinulata var. elegans

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• 作者：Fangfang Xu^a ; ¹ ; Kangsheng Liao^a ; ¹ ; Yuhong Liu^b ; Zhenbiao Zhang^b ; Dean Guo^c ; ^{daguo@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author} ; Ziren Su^b ; ^{suziren@gzucm.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Bo Liu^a ; ^{doctliu@263.net" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Biotransformation ; Patchoulol ; Cunninghamella echinulata var. elegans ; X-ray crystallography
• 刊名：Fitoterapia
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：109
• 期：Complete
• 页码：201-205
• 全文大小：564 K

文摘

Biocatalysis of patchoulol (PA) was performed by the fungus Cunninghamella echinulata var. elegans. Eight metabolites (1–8) including four new compounds were obtained, and their structures were elucidated as (5R,8S)-5,8 dihydroxypatchoulol (1), (5R*,9R*)-5,9 dihydroxypatchoulol (2), (6S*, 9S*)-6,9 dihydroxypatchoulol (3), and (4R*)-4 hydroxypatchoulol (4) by spectroscopic analysis. The absolute configuration of 1 was determined by single crystal X-ray diffraction.