Microbial transformation of contraceptive drug etonogestrel into new metabolites with Cunninghamella blakesleeana and Cunninghamella echinulata
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- 作者：Elias Baydouna ; eliasbay@aub.edu.lb" class="auth_mail" title="E-mail the corresponding author ; Atia-tul Wahabb ; Nayab Shoaibc ; Malik Shoaib Ahmadc ; Roula Abdel-Massihd ; Colin Smitha ; Nimra Naveedc ; M. Iqbal Choudharyb ; c ; e ; iqbal.choudhary@iccs.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Etonogestrel ; Contraceptive ; Biotransformation ; Cunninghamella blakesleeana ; Cunninghamella echinulata ; β-Glucuronidase inhibition ; Colon cancer
- 刊名：Steroids
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：115
- 期：Complete
- 页码：56-61
- 全文大小：504 K
文摘
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Five metabolites of contraceptive drug etonogestrel (1) were synthesized through biotransformation by fungi.
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Biotransformation of 1Cunninghamella blakesleeana yielded metabolites 2–6.
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Biotransformation of 1Cunninghamella echinulata yielded metabolites 2, 4, and 6.
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6β-Hydroxy-etonogestrel (5) was found to be active against β-glucuronidase enzyme.