One step N-glycosylation by filamentous fungi biofilm in bioreactor of a new phosphodiesterase-3 inhibitor tetrazole
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- 作者：Paula L. de Melo Souzaa ; Evilanna L. Arrudaa ; Francine Pazinib ; Ricardo Menegattib ; Boniek G. Vazc ; Luciano M. Liã ; od ; Valé ; ria de Oliveiraa ; valeriaoliveira@ufg.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Glycosylation ; LQFM 021 ; Phosphodiesterase-3 inhibitor ; Cunninghamella ; Biofilm bioreactor
- 刊名：Bioorganic & Medicinal Chemistry Letters
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：26
- 期：13
- 页码：3177-3181
- 全文大小：997 K
文摘
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An efficient and rapid process for N-glycosylation of 5-(1-(3-fluorophenyl)-1H-pyrazol-4-yl)-2H- tetrazole.
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Filamentous fungi biofilm in bioreactor was successfully developed.
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N-Glycosyl yield of 68% was obtained with Cunninghamella echinulata ATCC 9244 biofilm in bioreactor.