Production of a new pyridine N-oxide by bioconversion with Cunninghamella echinulata var. elegans
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- 作者：Jia Zeng ; David Gage ; Jixun Zhan
- 关键词：Cunninghamella echinulata var. elegans ; Biotransformation ; Pyridine ; N-Oxidation ; Selective ; Efficient
- 刊名：Journal of Bioscience and Bioengineering
- 出版年：2012
- 出版时间：November, 2012
- 年：2012
- 卷：114
- 期：5
- 页码：497-499
- 全文大小：316 K
文摘
A new N-oxide was produced from 3-(N-Boc-aminomethyl)-5-bromopyridine by bioconversion with Cunninghamella echinulata var. elegans ATCC 9245, and its structure was established based on the spectral data. The microbial N-oxidation is efficient and highly selective. The substrate was transformed into the product in 7 days.