Biosynthesis and antioxidant activity of 4NRC 尾-glycoside

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• 作者：Kelly C.F. Ara煤jo Cordeiro ; K锚nnia R. Rezende ; Boniek G. Vaz ; W ; erson Rom茫o ; Luciano M. Li茫o ; Eric de Souza Gil ; Val茅ria de Oliveira
• 关键词：Glycosylation ; 4-Nerolidylcatechol ; Cunninghamella ; 4NRC-尾-glycoside
• 刊名：Tetrahedron Letters
• 出版年：27 November, 2013
• 年：2013
• 卷：54
• 期：48
• 页码：6656-6659
• 全文大小：557 K

文摘

This Letter describes glycosylation of 4-Nerolidylcatechol (4-NRC) the major secondary metabolite from Pothomorphe peltata and Pothomorphe umbellata showing remarkable antioxidant, antimalarial, anti-inflammatory, and anti-HIV activities. One step biosynthesis was catalyzed by Cunninghamella echinulata ATCC 9245 and the reaction was undertaken in PDSM medium at 27 掳C, 200 rpm for 96 h. After purification by silica gel flash column chromatography the 4-NRC 尾-glycoside was identified by ultrahigh resolution mass spectrometry and ¹H NMR. The antioxidant activity was evaluated by differential pulse voltammetry.