Inhibitors of osteoclastogenesis from Lawsonia inermis leaves
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- 作者：Nguyen Xuan Cuong ; Nguyen Xuan Nhiem ; Nguyen Phuong Thao ; Nguyen Hoai Nam ; Nguyen Tien Dat ; Hoang Le Tuan Anh ; Le Mai Huong ; Phan Van Kiem ; Chau Van Minh ; Ji-Hee Won ; Won-Yoon Chung ; Young Ho Kim
- 关键词：Lawsonia inermis ; Lythraceae ; Osteoporosis ; Osteoclast
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2010
- 出版时间：15 August 2010
- 年：2010
- 卷：20
- 期：16
- 页码：4782-4784
- 全文大小：286 K
文摘
Ten phenolic compounds (1–10) were isolated from a methanol extract of Lawsonia inermis leaves including two new ones, lawsoniasides A (1) and B (2). Their structures were elucidated by spectroscopic methods (NMR and FTICRMS) in combination with acid hydrolysis and GC analyses. Compounds 4 and 5 showed a significant inhibition on receptor activator for nuclear factor-κB ligand-induced osteoclast formation in murine bone-marrow macrophages.