Inhibition by polycyclic aromatic hydrocarbons of ATPase activities in Sebastiscus marmoratus larvae：Relationship with the development of early life stages

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• 作者：Ruixia Li^a ; Zhenghong Zuo^a ; Donglei Chen^a ; Chengyong He^a ; Rong Chen^b ; Yixin Chen^a ; Chonggang Wang^a ; ^b ; ^{cgwang@xmu.edu.cn}
• 关键词：ATPase activity ; Developmental abnormality ; Fish ; Larvae ; Polycyclic aromatic hydrocarbons ; Sebastiscus marmoratus
• 刊名：Marine Environmental Research
• 出版年：2011
• 出版时间：February 2011
• 年：2011
• 卷：71
• 期：1
• 页码：86-90
• 全文大小：442 K

文摘

Sebastiscus marmoratus larvae were exposed to waterborne polycyclic aromatic hydrocarbons (PAHs) containing 3–5 rings, benzo[a]pyrene (BaP), pyrene (Py) or phenanthrene (Phe), respectively at 0.01, 0.1 and 1 μg L⁻¹. Cumulative mortality, frequency of dorsal curvature and rate of pericardial and yolk sac edema in larvae treated for 8 days were significantly increased in a dose-dependent manner. All three PAHs resulted in reduction of the lower jaw, and the extent of reduction increased with increasing concentrations of the PAHs. Na⁺/K⁺-ATPase and Ca²⁺-ATPase activity in larvae exposed to the three PAHs were all significantly inhibited in a dose-dependent manner. Analysis using the Pearson correlation coefficient indicated a significant correlation between the rate of the dorsal curvature and edema and the inhibition of Na⁺/K⁺-ATPase and Ca²⁺-ATPase activity, suggesting that the developmental defects caused by PAHs were related to their inhibition of Na⁺/K⁺-ATPase and Ca²⁺-ATPase activity.