3-Ethyl-6-methyl-isocytosines: Synthesis and Solid State Structural Analysis

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• 作者：Custelcean ; Radu ; Craciun ; Liliana
• 关键词：dispersion interactions ; hydrogen bonding ; isocytosine ; self-assembly
• 刊名：Tetrahedron
• 出版年：2000
• 出版时间：July 14, 2000
• 年：2000
• 卷：56
• 期：29
• 页码：5067-5075
• 全文大小：231 K

文摘

The syntheses and solid state structures of 3-ethyl-6-methyl-5-alkyl-isocytosines (alkyl=H, Me, Et, n-Pr, n-Bu) are presented. These heterocycles consistently self-assemble into N–HN hydrogen-bonded dimers, which further associate by N–HO=C interactions, or N–HO–HO=C hydrogen bonds involving water of crystallization, generating extended supramolecular networks. Crystal packing analysis indicates that although hydrogen bonding is the primary intermolecular interaction in these molecular crystals, the dispersion forces may play a decisive role in determining their final three-dimensional arrangements.