2,2,3,3,11,11,12,12-Octamethyl-1,4,7,10,13-pentaoxacyclohexadecane: improved synthesis and crystal structure with NaSCN

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• 作者：Fanny Loustau-Chartez ; Rachel M. Robeson ; Radu Custelcean ; Richard A. Sachleben ; Peter V. Bonnesen
• 关键词：Crown ether ; Improved synthesis ; 16-Crown-5 ; Sodium
• 刊名：Tetrahedron Letters
• 出版年：2009
• 出版时间：17 June 2009
• 年：2009
• 卷：50
• 期：24
• 页码：2936-2938
• 全文大小：317 K

文摘

An efficient synthesis of 2,2,3,3,11,11,12,12-octamethyl-1,4,7,10,13-pentaoxacyclohexadecane (1, OM16C5) is described, which affords over an order of magnitude improvement in yield over the previously reported method. The first X-ray crystal structure of 1, as a complex with NaSCN, is also reported.