Icariin inhibits atherosclerosis progress in Apoe null mice by downregulating CX3CR1 in macrophage
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- 作者：Yao Wanga ; Yun-Shan Wangb ; Shu-Liang Songb ; Hao Liangb ; Ai-Guo Jia ; b ; jiaiguo@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Icariin ; Atherosclerosis ; CX3CR1 ; Apoe null mice
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：19 February 2016
- 年：2016
- 卷：470
- 期：4
- 页码：845-850
- 全文大小：2566 K
文摘
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Microarray analyses identified downregulation of CX3CR1 after icariin treated.
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Icariin treatment significantly reduced lesion area in Apoe null mice.
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Icariin treatment significantly reduced macrophage infiltration in Apoe null mice.
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Icariin reduced CX3CR1 and CX3CL1 protein levels in the artery wall and serum.