Altered microglia morphology and higher resilience to stress-induced depression-like behavior in CX3CR1-deficient mice
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- 作者：Sabine Hellwiga ; sabine.hellwig@uniklinik-freiburg.de" class="auth_mail" title="E-mail the corresponding author ; Simone Brioschia ; Sandra Dienia ; Lars Fringsb ; c ; Annette Masucha ; Thomas Blankd ; Knut Bibera ; e ; knut.biber@uniklinik-freiburg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Depression ; Fractalkine ; CX3CR1 ; CX3CL1 ; Stress ; Microglia
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：55
- 期：Complete
- 页码：126-137
- 全文大小：3448 K
文摘
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CX3CR1-deficient mice are resistant to chronic stress in the CDM model.
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Microglia in wild type animals show hyper-ramification in the CDM model.
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Microglia hyper-ramification may be crucial for depressive-like behavior development.