CD16+ monocytes are efficiently recruited to endothelial cells (EC) in presence of LPS.
TNF release is amplified upon CX3CR1-dependet CD16+ monocyte adhesion to EC.
Fractalkine shed by CD16+ monocytes interferes with CD3CR1-dependent cell adhesion.
Shedding of fractalkine thereby balances TNF release and CD16+ monocyte recruitment.