CX3CR1 deficiency attenuates imiquimod-induced psoriasis-like skin inflammation with decreased M1 macrophages
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- 作者：Sohshi Morimura1 ; Tomonori Oka1 ; Makoto Sugaya ; sugayam-der@h.u-tokyo.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Shinichi Sato
- 关键词：Ab ; antibody ; CX3CR1 ; CX3C chemokine receptor 1 ; DC ; dendritic cell ; ELISA ; enzyme-linked immunosorbent assay ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase ; H&E ; hematoxylin and eosin ; HPF ; high power field ; IMQ ; imiquimod ; KC ; keratinocyte ; NK ; natural killer ; PBS ; phosphate-buffered saline ; RT ; reverse transcription ; TLR ; toll like receptor ; WT ; wild-type
- 刊名：Journal of Dermatological Science
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：82
- 期：3
- 页码：175-188
- 全文大小：3553 K
文摘
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CX3CR1 deficiency attenuated imiquimod-induced psoriasis like skin inflammation.
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CX3CL1/CX3CR1 interaction is important for infiltration of M1 macrophages.
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Decrease in M1 macrophages in the skin may attenuate psoriasis-like inflammation.